Pharmacokinetic Aspects of Biliary Excretion. Dose Dependency of Riboflavin in Rat
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Biliary excretion of lead in the rat.
Studies have been made in the rat of the elimination of 210Pb in the bile after the intravenous injection of ioo ,ug. of lead. Four groups of rats were used: in two the bile was drained by cannulation of the bile duct, and in the other two the bile flow to the duodenum was interrupted by ligation or division of the bile duct. The radioactivity of the bile, of the intestinal walls, and of the in...
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Liquorice is a commonly prescribed herb in traditional Chinese medicine with the primary constituent, glycyrrhetinic acid (GA) responsible for the toxic effects arising from its chronic consumption. Hepatic transformation and biliary excretion of GA are significant and well-documented pharmacokinetic pathways in humans, while glucuronide conjugates are the major identified metabolites. Here we ...
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The biliary excretion of linamarin (2[beta-D-glucopyranosyloxy]isobutyronitrile) was studied in male albino Wistar rats injected i.p. with single doses of 300 mg linamarin/kg following cannulation of the bile duct in vivo; 24 hr faeces of uncannulated rats, similarly dosed, was examined for excretory products. Enzymatic and spectrophotometric analyses of the bile exudate showed that glucosidic ...
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1. (14)C-labelled amphetamine and methamphetamine were injected into rats cannulated at the bile duct under thiopentone anaesthesia and the output of their metabolites in urine and bile was determined. 2. With amphetamine, 69% of the (14)C was excreted in the urine and 16% in the bile in 24h. The main metabolite in bile was the glucuronide of 4-hydroxyamphetamine. The output of unchanged amphet...
متن کاملStudies on biliary excretion of alkaline phosphatase in the rat.
Although the amount of alkaline phosphatase in the serum has been used as a clinical test for several decades, there is still controversy over the wvay in which the increased levels found in hepatobiliary diseases are reached. It has been generally believed that the increased enzyme activity in the serum commonly observed results from some combination of decreased excretion in the bile and, in ...
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ژورنال
عنوان ژورنال: Chemical and Pharmaceutical Bulletin
سال: 1970
ISSN: 0009-2363,1347-5223
DOI: 10.1248/cpb.18.228